ANTI-INFLAMMATORY PREDICTION OF PERONEMIN COMPOUNDS FROM SUNGKAI (Peronema canescens Jack) AND THEIR DERIVATIVES

Seven Sungkai Peronemins compounds belong to the alkaloid group, Peronemin A2, A3, B1, B2, B3, C1, and D1. contains several bioactive compounds, triterpenoids, alkaloids, flavonoids, phenolics, steroids, saponins which can act as anti-inflammatory candidates. Geometry optimization find most stable molecular structure SMILES of peronemin compound was used predict pIC50 using pChEMBL® program. From test results seven candidate target molecules were obtained potential agents, namely Angiotensin II type 2 (AT-2) receptors, Dihydrofolate reductase, Phosphodiesterase 7A. Of three molecules, receptor on C1 has highest value 6.79. The indicates an exponentially potent inhibitor in determining its biological activity. function AT-2 is revealed by involvement modulating mediators such cytokines chemokines.